Effects of emodin on rat poisoning respiratory failure induced by organic phosphorus
- VernacularTitle:大黄素对有机磷中毒诱发呼吸衰竭大鼠干预作用研究
- Author:
Yongmei YUAN
;
Zhaoxia NIU
;
Jing CHENG
;
Dongge CHANG
;
Ning YANG
- Publication Type:Journal Article
- Keywords:
emodin;
cholinesterase inhibitors;
organic phosphorus;
respiratory failure
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the intervention effect of emodin on organophosphorus poisoning induced respiratory failure.Methods 60 male Wistar rats of clean grade were randomly divided into:normal control group, model control group, positive drug group and emodin group, with 15 rats in each group.Except the normal control group rats were given intraperitoneal anesthesia, the right common carotid artery intubation, when rats stayed awake began a septic model.Blood gas analysis and serum level of oxygen free radicals and respiratory rate were compared before poisoning, respiratory failure, intervention of 5, 10, 30 min.Results Mouth breathing, slow respiratory frequency and cyanosis, appeared after exposure.Respiratory frequency decreased after exposure , compared with the positive drug group, respiratory frequency of emodin group 10 min and 30 min was higher ( P<0.05), PaO2, SaO2, BE decreased, PaCO2 increased after respiratory failure, Compared with the positive drug group, PaO2, PaCO2, SaO2 and BE of emodin group for the treatment of 10 min, 30 min was higher,(P <0.05).The level of oxygen free radicals in rats of each group had no significant difference before the exposure and the respiratory failure.Compared with the positive drug group, SOD and MDA of emodin group in 30 min after intervention were higher,( P<0.05 ) .Conclusion Emodin can improve the respiratory frequency of organic phosphorus poisoning induced respiratory failure ,improve blood gas analysis of the indicators and the level of oxygen free radicals.
