Correlation and differences in proto oncogene protein of patients with OLK and OSCC
- VernacularTitle:OLK患者与OSCC癌患者的原癌基因蛋白差异及相关性研究
- Author:
Weiwei LI
;
Qiling WEI
;
Jinhui YANG
;
Jing TONG
;
Qiuping CUI
- Publication Type:Journal Article
- Keywords:
oral leukoplakia;
oral squamous cell carcinoma;
MDM2;
p53;
Ki-67
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the significance of proto oncogene protein in oral squamous cell carcinoma and oral leukoplakia.Methods 40 patients who were diagnosed with oral leukoplakia (OLK),40 patients who were diagnosed with oral squamous cell carcinoma(OSCC),and at the same time, 40 healthy volunteers as control group were collected.the lesions and normal oral mucosa were taken as samples, left supernatant after grinding, MDM2 protein, p53 protein and Ki-67 protein were detected by ELISA in three groups,and analyse the correlation between three groups.Results Among three groups,MDM2, p53 expression:OSCC group>OLK group>control group (P<0.05).Ki-67 expression level among three groups, OSCC group>OLK group>control group (P<0.05).MDM2, p53, Ki-67 expression had a positive correlation in OSCC group and OLK group (P<0.05), but there was no obvious correlation in control group.Conclusion When oral leukoplakia developes into oral squamous cell carcinoma, MDM2, p53, Ki-67 shows high expression, and there is a positive correlation between MDM2, p53, Ki-67.
