Effect of melatonin on serum MDA, NF-κB, TNF-αand β2-MG levels in secondary brain damage following intracerebral hemorrhage patients
- VernacularTitle:褪黑素对脑出血继发脑损伤患者血清MDA、NF-κB、TNF-α及β2-MG水平的影响
- Author:
Feng GAO
;
Xiang GAO
- Publication Type:Journal Article
- Keywords:
melatonin;
secondary brain damage following intracerebral hemorrhage;
malondialdehyde;
NF-κB;
tumor necrosis factor α;
β2-microglobulin
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):71-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of melatonin on serum malondialdehyde (MDA), NF-κB, tumor necrosis factor-α(TNF-α) andβ2-microglobulin (β2-MG) levels in secondary brain damage following intracerebral hemorrhage patients.Methods 90 patients secondary brain damage following intracerebral hemorrhage were divided into experimental group and control group, 45 cases in each group.The control group were given conventional treatment after surgical removal of hematoma, and the experimental group, on the basis of control group, were given melatonin capsule (6 mg melatonin) , orally, once a day, for 2 weeks treatment.The levels of MDA, NF-κB, TNF-αand β2-MG in patients’ serum were detected.Results The MDA, NF-κB, TNF-αand β2-MG levels after treatment significantly decreased compared with before treatment in two groups (all P<0.05), and the above indexes in experimental group significantly decreased compared with control group ( P <0.05 ).Conclusion Melatonin can significantly reduce the levels of MDA, NF-κB, TNF-αand β2-MG levels in brain injury patients with cerebral hemorrhage, and repair brain damage, which has a guiding significance for clinical use.
