Study on effect of pidotimod on TH1/TH2 balance and immune factor in patients with severe trauma
- VernacularTitle:匹多莫德对重症外伤患者TH1／TH2及免疫因子影响研究
- Author:
Xiaotao LI
;
Hui FU
;
Hui ZHOU
- Publication Type:Journal Article
- Keywords:
pidotimod;
severe trauma;
TH1/TH2;
immune factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):74-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of pidotimod on TH1/TH2 balance and immune factor in patients with severe trauma.Methods 90 cases with severe chest trauma patients were randomly divided into two groups.45 cases in control group were treated by conventional anti-inflammatory treatment, 45 cases in experimental group on base of control group with pidotimod 800mg /times, 1 times daily.After treatment, the serum levels of IL-4, IFN-γ, IL-2, IL-10, IL-17,IgM, IgA and IgG were compared.Results Compared with before treatment, indexes were improved(P<0.05). Compared with the control group, IL-4 level was lower, IFN-γlevel was higher, IFN-γ/IL-4 was higher(P<0.05).IL-2, IL-10, IL-17 level was higher(P<0.05).IgA, IgM, IgG level was higher(P<0.05).Conclusion Pidotimod can balance the TH1/TH2 in the patients with severe trauma, and adjust the serum levels of IgM, IgA and IgG,can be used in clinical application.
