Changes of intercellular adhesion molecular-l and vaseular cell adhesion molecular-l in patients with pancreatic cancer
- VernacularTitle:组织内及外周血细胞间粘附分子-1与血管细胞间粘附分子-1在胰腺癌患者中的变化研究
- Author:
Jian QIAN
;
Yao CHEN
;
Lelong QI
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
ICAM-1;
VCAM-1;
sICAM-1;
sVCAM-1
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):80-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of VCAM-1 and ICAM-1 levels in tumor and peripheral blood in pancreatic cancer patients. Methods 28 cases with pancreatic cancer were selected from August 2013 to Octorber 2014 as experiment group,28 cases with acute pancreatitis who needed removal of pancreas as control group,28 healthy people as normal group.ICAM-1 and VCAM-1 in tissue were compared and sVCAM-1 and sICAM-1 in serum were compared.Results ICAM-1 and VCAM-1 in tissue of experiment group were significantly higher than normal group(P<0.05), sICAM-1,sVCAM-1 in serum of experiment group were higher than control group and normal group(P<0.05),there were no correlation between CEA and sICAM-1,sVCAM-1 in serum of experiment group(r=0.116,P>0.05;r=0.093,P>0.05),there were positive correlation between CA19-9 and sICAM-1,sVCAM-1 in serum of experiment group(r=0.573,P<0.01;r=0.435,P<0.05).Compared with pre-operation, the serum concentrations of sVCAM-1 and sICAM-1 were lower(P<0.05).Conclusion ICAM-1 and VCAM-1in pancreatic cancer patients are significantly higher than that in acute pancreatitis patients and healthy people, the correlation of ICAM-1 and VCAM-1 expression in pancreatic cancer, early diagnosis and treatment of pancreatic cancer has important significance.
