Receptor tyrosine kinases in osteosarcoma and Ewing sarcoma

VernacularTitle:受体酪氨酸激酶在骨肉瘤和尤文肉瘤中的作用
Author: Guoqi SHEN ; Chunlin ZHANG
Publication Type:Journal Article
Keywords: Receptor protein-tyrosine kinases; Osteosarcoma; Sarcoma,Ewing's; Drug therapy
From: Journal of International Oncology 2015;(7):551-553
CountryChina
Language:Chinese
Abstract: Osteosarcoma and ewing sarcoma are the two most common types of primary malignant bone tumors. Receptor tyrosine kinases(RTKs),including varieties of cell growth factors and proto-oncogene pro-ducts,are the high-affinity cell surface receptors which play an important role in the normal physiological func-tion of cells. A large number of studies have demonstrated that the abnormal RTKs signaling pathways may pro-mote the tumorigenesis and development of osteosarcoma and ewing sarcoma by affecting tumor cell survival, proliferation,invasion and metastasis. Targeting treatment of RTKs is a promising therapeutic approach for osteosarcoma and ewing sarcoma.