Receptor tyrosine kinases in osteosarcoma and Ewing sarcoma
10.3760/cma.j.issn.1673-422X.2015.07.021
- VernacularTitle:受体酪氨酸激酶在骨肉瘤和尤文肉瘤中的作用
- Author:
Guoqi SHEN
;
Chunlin ZHANG
- Publication Type:Journal Article
- Keywords:
Receptor protein-tyrosine kinases;
Osteosarcoma;
Sarcoma,Ewing's;
Drug therapy
- From:
Journal of International Oncology
2015;(7):551-553
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma and ewing sarcoma are the two most common types of primary malignant bone tumors. Receptor tyrosine kinases(RTKs),including varieties of cell growth factors and proto-oncogene pro-ducts,are the high-affinity cell surface receptors which play an important role in the normal physiological func-tion of cells. A large number of studies have demonstrated that the abnormal RTKs signaling pathways may pro-mote the tumorigenesis and development of osteosarcoma and ewing sarcoma by affecting tumor cell survival, proliferation,invasion and metastasis. Targeting treatment of RTKs is a promising therapeutic approach for osteosarcoma and ewing sarcoma.