Value of established solid-organ transplant tolerance from experience of host im-munomodulation with helminth infection
10.3969/j.issn.1000-484X.2015.06.002
- VernacularTitle:蠕虫感染的免疫调节作用在诱导器官移植免疫耐受中应用价值的探讨
- Author:
Yingzi MING
;
Yizhou ZOU
- Publication Type:Journal Article
- Keywords:
Helminthic infection;
Immune regulation;
Organ transplantation;
Immune tolerance
- From:
Chinese Journal of Immunology
2015;(6):728-731
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is the effective method to replace the function of the patient failed organ. But it is very disappoint that recipients have to receive the long-term immunosuppression regimens for prevention of allograft rejection. To induce allograft immune tolerance without immunosuppressant is in great demand. Although several tolerance strategies for organ transplant have been proposed, even some has already been tested in the 1st clinical trial, these strategies haven ' t approached to ideal efficacy. Helminths are remarkably successful parasites to achieve immunological tolerance to host immune response. It is now well established that the parasites′ success is the result of active immunomodulation of their hosts ' immune response. We suggest that injecting B cells from donor spleen and helminth soluble antigens, recipient might become tolerance to donor organ, but not tolerated to other antigens. Research based on this approach has great translated value for future clinic practice.
