Molecular mechanism of long non-coding RNAs in tumor drug resistance
10.3760/cma.j.issn.1673-422X.2015.06.010
- VernacularTitle:长非编码 RNA 在肿瘤耐药机制中的研究进展
- Author:
Yifan LIAN
;
Keming WANG
- Publication Type:Journal Article
- Keywords:
RNA;
Neoplasms;
Drug tolerance;
Signal transduction
- From:
Journal of International Oncology
2015;(6):439-441
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs)are closely related to the tumorigenesis,proliferation, metastasis and clinical outcome,whihc play important roles in the process of drug resistance of many tumor cells.Recently,research indicates that many lncRNAs regulate drug resistance of tumor cells through a variety of signaling pathways both in vitro and in vivo.Furthermore,it is also found that after blocking the relevant tar-gets can reverse this chemoresistance.
