Clinical study of anti-Mullerian hormone in prediction of ovarian aging

VernacularTitle:抗苗勒管激素与年龄的关系及其预测卵巢衰老的临床研究
Author: Lihong GAO ; Wenwei CAI ; Qin ZHU ; Yongxiang LI ; Qianyan JIN ; Meiguang ZHANG ; Yingru CAI ; Zhiting ZHOU ; Xiaojie WU
Publication Type:Journal Article
Keywords: Ovary; Anti-Mullerian hormone; Age factors; Cell aging
From: Chinese Journal of Obstetrics and Gynecology 2015;(5):352-355
CountryChina
Language:Chinese
Abstract: Objective To explore the serum anti-Mullerian hormone (AMH) level in women of childbearing age with normal menstrual cycles. Methods A total of 1 423 women with regular menstrual cycles were selected and divided into 5 groups according to their ages, i.e.≤25, 26-30, 31-35, 36-40,≥41 years. Their serum levels of AMH were measured, and the relationship between AMH and age was analyzed. Results The serum AMH levels of 5 groups according to ages (≤25, 26-30, 31-35, 36-40, ≥41 years) were 3.62, 3.10, 2.27, 1.07, 0.45μg/L, respectively. The comparison of serum AMH levels in different age groups had significant difference (P<0.01). Serum AMH level declined with increasing age,and dropped significantly after 36. The serum AMH level and age showed a negative correlation with significant difference (r=-0.374, P<0.01). Quadratic regression of logAMH proximally reflected the relationship between AMH and age. Conclusion AMH determination for women of childbearing age could provide reference for the evaluation of ovarian function.