MR guided focused ultrasound for treating uterine fibroids:a Meta analysis
10.3760/cma.j.issn.1005-1201.2015.05.016
- VernacularTitle:MR引导高强度聚焦超声治疗子宫肌瘤的Meta分析
- Author:
Guangyao WU
;
Guoli DONG
;
Hanfeng YANG
;
Wenxuan WANG
;
Yucheng HUANG
- Publication Type:Journal Article
- Keywords:
Magnetic resonance guided focused ultrasound;
high frequency focused ultrasound;
magnetic resonance;
uterine fibroids;
Meta analysis
- From:
Chinese Journal of Radiology
2015;(5):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the recent effect and safety of magnetic resonance guided focused ultrasound (MRgFUS) for treating uterine fibroids with a Meta analysis. Methods Such databases as Cochrane Library,PubMed,EMbase, CBM,CNKI,CQVIP and Wanfang were searched from their establishment. After thestudy selected, assessment and data extraction conducted by two reviewers independently, Meta-analysis were performed by using the Comprehensive Meta-analysis V2 software. The volume of non-perfusion ratio (NPVR), fibroid shrinkage, clinical symptom severity (SSS score) and adverse reactions were analyzed.Results Nighteen retrieved articles were included, with a total of 1 549 patients. The results of Meta-analysis showed that:(1)nonperfused volume ratio (NPVR),Mean=57.1%(95%CI 45.0% —69.2%).(2)Percentage of FBs shrinkage:mean=31.4% (95% CI 29.2% —33.6%).(3)Symptom severity score (SSS):baseline mean=51.00(95%CI 41.61—60.40),3 months mean=32.50 (95%CI 25.90—39.10),6 months mean=28.62(95%CI(23.57—33.66),12 months mean=24.46(95%CI 15.44—33.49), the average of the severity score of the patient symptoms had a tendency to reduce.(4)The degree of adverse reactions were mild and could relieve itself, there was fewer serious adverse reactions. Conclusions The current evidence indicates that MRgFUS in treatment of uterine fibroidsis reliable and safe. MRgFUS can significantly reduce the volume and the symptom severity score ofthe patients.
