Evaluation of the efficacy of botulinum toxin type A in the treatment of trigeminal neuralgia

VernacularTitle:A 型肉毒素治疗三叉神经痛的系统评价
Author: Zhihong LIANG ; Renhuan HUANG ; Zongdao SHI
Publication Type:Journal Article
Keywords: Trigeminal neuralgia; Botulinum toxin type A(BTX-A); Randomized controlled trials
From: Journal of Practical Stomatology 2015;(3):401-406
CountryChina
Language:Chinese
Abstract: Objective:To review the clinical efficacy of botulinum toxin type A(BTX-A)in the treatment of trigeminal neuralgia (TN).Methods:The main bibliographic databases were searched from English and Chinese literatures on the topic and the refer-ences of the identified articles were also searched for additional studies.2 reviewers assessed the quality of the included studies and extracted data duplicate.Results:3 Chinese and 1 English reports with 203 participants were included.However,substantial hetero-geneity(I2 =77%)precluded meta-analysis and the results were individually described.3 trials reported that BTX-A was more effec-tive than the control and 1 showed no difference between groups.Adverse effects of BTX-A were reported in 4 reports and were mild to moderate.Conclusion:BTX-A is effective in treating TN with few adverse effects.However,the evidence is weak because of a few studies included and most of them with low methodological quality.Further studies with high quality are needed to testify the evidence.