The clinical effect of dexmedetomidine in early psychosis prevention after liver transplantation

VernacularTitle:右美托咪定预防肝移植术后早期精神异常的临床效果观察
Author: Zhi FU ; Xin WANG ; Yuanyuan ZHANG ; Lu WANG ; Dongdong LIN
Publication Type:Journal Article
Keywords: liver transplantation; Psychosis; Dexmedetomidine
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(11):1648-1650
CountryChina
Language:Chinese
Abstract: Objective To investigate effects and safety of dexmedetomidine on the prevention of abnormal mental in patients after liver transplantation.Methods 160 patients after liver transplantation were randomly divided into the two groups using the drawing method:midazolam group(n =80),dexmedetomidine group(n =80),compared the two groups of patients with general,mental abnormality and the occurrence of adverse reactions.Results There were no significant differences in the general situation (gender,age,postoperative ventilator time,ICU stay time,oper-ation time,blood FK506 concentration,APACHEII score 24 hours after operation)of the two groups of patients (P >0.05),the spirit of the abnormal rate of the observation group was lower than that of the control group (P =0.009), incidence of hypotension and hypertension in the observation group was higher than that in the control group (P =0.035,0.029).Conclusion Dexmedetomidine can effectively reduce the postoperative mental disorders in patients in the early stage after liver transplantation.