Expression of synaptosomal-associated protein in non-small cell lung cancer
- VernacularTitle:肺腺癌患者突触小体相关蛋白家族的表达研究
- Author:
Xing HUANG
;
Shimin LU
;
Xin WANG
;
Chen CHEN
;
Jie WANG
;
Lin XU
;
Binhui REN
- Publication Type:Journal Article
- Keywords:
SNAP47;
SNARE protein;
Non-small cell lung cancer;
Invasion and metastasis;
Real-time PCR
- From:
Journal of Medical Postgraduates
2015;(6):600-603
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract ] Objective Numerous studies had shown that synaptic-associated proteins (SNAPs) were closely related to the occurrence and development of tumors .The aim of this study was to investigate the expression of synaptosomal-associated protein 47 (SNAP47) and its correlation with the clinicopathological features in non-small cell lung cancer(NSCLC). Methods The expres-sions of SNAP family (SNAP23, SNAP25, SNAP29 and SNAP47) were extracted and analyzed through the gene expression microarray and the cancer genome atlas ( TCGA) data-base.SNAP47 mRNA expression in 52 cases of lung adenocarcinoma and their correspond-ing normal tissues were detected by quantitative real-time PCR ( qRT-PCR) . Results Among 52 cases of lung adenocarcinoma , SNAP47 mRNA expression levels of 41 cases(78.9%) were significantly higher than the adjacent lung tissue (P<0.05).The mRNA level of SNAP47 was associated with lymph node invasion and advanced clinical patho-logical stage .The mRNA levels of SNAP47 of patients in II/III stage were significantly higher than those of I stage patients ( 6.558 ± 4.730 vs 2.718 ±2.370, P<0.05).The mRNA levels of N1+N2 were higher than those of N0 (6.609 ±4.942 vs 3.360 ±2.987,P<0.05). Conclusion The high specificity of SNAP47 expression in lung cancer tissues might be associated with the invasion and lymph node metastasis of NSCLC , which is the potential therapeutic target of lung cancer .
