Advances research in chromatin DNaseⅠhypersensitive sites and its transcriptional regulation function
- VernacularTitle:染色质 DNaseⅠ超敏感位点的定位及其转录调控功能的研究进展
- Author:
Wenqi YU
;
Yamei WANG
- Publication Type:Journal Article
- Keywords:
DNaseⅠhypersensitive sites;
High-throughput sequencing technology;
Transcriptional regulation functions
- From:
Journal of Medical Postgraduates
2015;(6):666-669
- CountryChina
- Language:Chinese
-
Abstract:
DNaseⅠhypersensitive sites (DHSs) are regions of extreme chromatin which is highly sensitive to DNaseⅠ.Ge-nome-wide mapping DHSs is a powerful method for identifying many different types of regulatory elements within nuclear chromatin .It can help systematically resolve gene and genomic information , and the dynamic molecular mechanism of transcriptional regulation .This paper reviews the distribution of DHSs , the technology of DNase-seq and the research progress in transcriptional regulation functions of DHSs.
