Biological functions of alternative polyadenylation
10.7644/j.issn.1674-9960.2015.05.018
- VernacularTitle:可选择性多聚腺苷酸化的生物学功能
- Author:
Liang YANG
;
Hongxing ZHANG
;
Ying CUI
;
Gangqiao ZHOU
- Publication Type:Journal Article
- Keywords:
alternative polyadenylation;
gene regulation;
RNA binding protein;
microRNA;
neoplasms
- From:
Military Medical Sciences
2015;(5):393-397
- CountryChina
- Language:Chinese
-
Abstract:
Alternative polyadenylation ( APA) is a widespread phenomenon and an important layer of gene regulation . APA contributes to the complexity of the transcriptome by allowing a single gene to encode multiple mRNA isoforms that dif -fer either in their coding sequence or in their 3′untranslated regions (3′UTR).The length of the 3′UTR can affect the sta-bility, localization and efficiency of the messenger RNAs ( mRNAs) by altering binding sites of RNA binding proteins or mi-croRNAs(miRNAs).The polyadenylation process , mechanisms governing APA and biological consequences resulting from APA are only starting to be deciphered .Here, we review the research progress in APA .
