Analysis of frequency of HLA-B*5801 in population of Chinese Minnan region
10.3969/j.issn.1000-484X.2015.05.018
- VernacularTitle:闽南地区人群中HLA-B*5801基因频率的分析
- Author:
Xun LI
;
Yinghao HE
;
Chaoyang HUANG
;
Jiaqin ZHANG
;
Xiaohui LU
;
Bin HU
;
Xiuyu SONG
- Publication Type:Journal Article
- Keywords:
Chinese Minnan region;
HLA-B*5801;
Gene frequency
- From:
Chinese Journal of Immunology
2015;(5):663-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the gene frequency of HLA-B* 5801 in the population of Chinese Minnan region.Methods:In this study,we enrolled 178 patients requiring allopurinol therapy( including 40 patients with gout,89 patients with hyperuricemia and 49 patients with gouty arthritis) and 100 healthy people.We isolated genomic DNA from their blood and screened for HLA-B*5801 with both PCR and gene sequencing.Results:We found 22%patients and 16%healthy people with HLA-B*5801.The frequencies of HLA-B*5801 in patients and healthy people are 0.13 and 0.09,respectively.The results from PCR and gene sequencing were consistent.Conclusion:The frequency of HLA-B*5801 in the population of Chinese Minnan region is relatively high.Therefore,it is necessary to screen for HLA-B*5801 in allopurinol users before taking the medicine.
