Diagnostic significance of dendritic cells for chronic obstructive pulmonary dis-ease
10.3969/j.issn.1000-484X.2015.05.022
- VernacularTitle:树突状细胞对慢性阻塞性肺疾病的诊断意义
- Author:
Xueqing LIU
;
Luning JIANG
;
Min SONG
- Publication Type:Journal Article
- Keywords:
DCs;
COPD;
Flow cytometry
- From:
Chinese Journal of Immunology
2015;(5):678-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the levels of dendritic cells(DCs)in peripheral blood of patients with acute exacerbations of chronic obstructive pulmonary disease(AECOPD)and explore the relationship between the content of DCs with AECOPD.Methods:The levels of DCs subsets( mDCs and pDCs) in peripheral blood with thirty-four cases of AECOPD and fifteen cases of healthy persons were measured by flow cytometry with four-color fluorescent analysis;and the pulmonary function tests in every subjects were evaluated by spirometry.Results:Compared with the control group,the levels of mDCs and pDCs inAE COPD groups with GOLDⅠ,GOLDⅡ, GOLDⅢand ClassⅣwere significantly higher( P<0.05) ,and with the severity of lung function in AECOPD patients,the levels were also increased( P<0.05).Conclusion:The levels of mDCs and pDCs inAE COPD patients were higher and significantly correlated with the severity of the disease,suggesting that DCs may be involved in the inflammation reaction process of COPD.
