Primary study on change of STAT3-TLR2 signaling axis in Chlamydia trachomatis persistent infection
10.3969/j.issn.1000-484X.2015.05.002
- VernacularTitle:沙眼衣原体持续感染状态下STAT3-TLR2信号轴的变化初探
- Author:
Chunjing CHEN
;
En CHEN
;
Lin LIN
;
Qizhi LUO
;
Wei LI
;
Ping YU
- Publication Type:Journal Article
- Keywords:
Persistent infection;
IFN-γ;
Chlamydia trachomatis;
STAT3;
TLR2;
IL-1α
- From:
Chinese Journal of Immunology
2015;(5):585-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore in state of Chlamydia trachomatis persistent infection,the STAT3-TLR2 axis may be activated and mediating abnormal secretion of inflammatory cytokines.Methods: We established acute infection and IFN-γinduced persistent infection model of Ct in HeLa cell.Gene transcription, cytokine secretion and protein expression were detected by using qRT-PCR, ELISA and Western blot respectively in STAT3-TLR2 signaling axis in each Ct infection model.Results: Persistent Ct infections upregulated the transcription of TLR2,significantly increased both the secretion of inflammatory cytokine IL-1αand the expression of STAT3 and TLR2,moreover,enhanced the activation of STAT3 simultaneously.Conclusion: In the Ct persistent infection induced by IFN-γ,the STAT3-TLR2 signaling axis activated significantly in HeLa cell.
