Changes of myeloid derived suppressor cells and T cells in lung cancer mice
10.3969/j.issn.1000-484X.2015.05.004
- VernacularTitle:肺癌小鼠MDSC和T细胞变化
- Author:
Quanhui ZHENG
;
Yingwen LIU
;
Xuemei ZHANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
CD4+T cell;
CD8+T cell;
MDSC
- From:
Chinese Journal of Immunology
2015;(5):595-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of CD4+T cells,CD8+T cells and myeloid derived suppressor cells( MDSC) in immune organs of lung cancer mice.Methods: Lung cancer mouse models were made by subcutaneously injection of Lewis lung cancer cell line( LLC).The CD4+T cell,CD8+T cell and MDSC were detected by flow cytometry.Results:Compared to that of normal control mice,the ratio and numbers of CD4+and CD8+T cell were significantly decreased in the spleen and lymph nodes of lung cancer mice.The number of CD4+T cells had no significant change while CD8+T cells decreased in the bone marrow of lung cancer mice.However,the ratio and number of MDSC were significantly increased in the bone marrow,spleen and lymph nodes of lung cancer mice compared to that of normal control mice.Conclusion: The development of lung cancer leads to decreased T cells and increased MDSC;which may induce immune tolerance to tumor cells.
