Study on combination of Docetaxel and Capecitabine on angiogenesis and expression of related regulatory factors in breast precancerous of rats
10.3969/j.issn.1000-484X.2015.05.013
- VernacularTitle:多西他赛联合希罗达对大鼠乳腺癌癌前病变组织 MVD、TGF-α与VEGF表达的影响
- Author:
Xiaohong LIAO
;
Yanping XIE
- Publication Type:Journal Article
- Keywords:
Docetaxel;
Capecitabine;
Mammary precancerous lesion;
MVD;
TGF-α;
VEGF
- From:
Chinese Journal of Immunology
2015;(5):638-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the reversal effect of Docetaxel and Capecitabine on rat breast precancerous from angiogenesis and expression of related regulatory factors VEGF mRNA in rats.Methods: 350 SD rats were divided into 7 groups.Model of rats mammary was induced by DMBA and was treated by Docetaxel and Capecitabine for 4 weeks.All of them were killed from 8th week.The microvascular were detected in the specimens, examination of histopathology was performed and the expression of VEGF mRNA was measured by in situ hybridization.Results:The rat mortality and the incidence of precancerous lesions increased obviously, and the incidence of precancerous lesion of the high-dose group and the middle dose reduced.The positive rate of the expression of MVD,TGF-αand VEGF mRNA tend to increase in all the groups.The positive-cell rate of VEGF mRNA of Docetaxel,Capecitabine, Docetaxel and Capecitabine in ADH was lower than in the model group,and the positive-cell rate of VEGF mRNA of Docetaxel and Capecitabine was lower than Capecitabine and Docetaxel separately.Conclusion: Combination of Docetaxel and Capecitabinecan decrease the expression of VEGF mRNA in precancerouslesion of rats mammary.
