Correlation between plasma asymmetric dimethylarginine and essential hypertension of Kazak and Han nationalities in Xinjiang
10.3969/j.issn.1671-8348.2015.15.021
- VernacularTitle:新疆哈萨克族、汉族血浆非对称二甲基精氨酸水平与原发性高血压的相关性研究
- Author:
Lian QIN
;
Zhong WANG
;
Li WANG
;
Shaoze CHEN
;
Hui TANG
;
Juncang DUAN
;
Hongqiang REN
- Publication Type:Journal Article
- Keywords:
Kazak nationality in Xinjiang;
asymmetric dimethylarginine;
hypertension
- From:
Chongqing Medicine
2015;(15):2072-2075
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between plasma asymmetric dimethylarginin(ADMA) and essential hyper‐tention(EH) by comparing the difference of plasma asymmetric dimethylarginine levels between Kazak and Han patients with EH in Xinjiang .Methods 91 Kazak and 112 Han patients with EH were selected .81 Kazak and 110 Han healthy people were selected as healthy control groups .The plasma ADMA levels in EH groups and the control groups were measured by using the reverse phase‐high performance liquid chromatography (RP‐HPLC) .Meanwhile the liver function ,renal function ,blood lipids ,blood glucose and fructosamine were measured .Results Kazak and Han patients with EH had higher levels of plasma ADMA than the control groups (P<0 .01);there was a positive correlation between the plasma ADMA and blood pressure levels of EH patients in two na‐tionalities(r=0 .715 ,P<0 .01 for Kazak ;r=0 .645 ,P<0 .01 for Han) .Conclusion Both Kazak and Han patients with EH have higher levels of ADMA than the respective healthy control group in Xinjiang .The correlation between the plasma levels of ADMA and EH existed ,which indicate that ADMA might be involved in the occurrence and development of EH .
