Meta-analysis of correlation between CYP2 D6 polymorphisms and tamoxifen concentrations and its activity in Chinese breast cancer patients
- VernacularTitle:中国人群CYP2D6的基因多态性与乳腺癌患者他莫昔芬及其代谢物血药浓度关系的Meta分析
- Author:
Xuan XIONG
;
Sichao ZHNAG
;
Changyu ZHU
- Publication Type:Journal Article
- Keywords:
tamoxifen;
CYP2D6;
meta-analysis;
systematic review
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the correlation between polymorphisms of CYP2D6 genotypes and concentrations of tamoxifen and its activity in Chinese breast cancer patients.Methods Such databases as Cochrane Library, PubMed, EMBase, CNKI, CBM, WeipuData and WanfangDate,from January 1995 to October 2014 were searched on line for the studies about the correlation between polymorphisms of CYP2D6 genotypes concentrations of tamoxifen and its activity in Chinese breast cancer patients.And references about it were checked.The meta-analysis was performed with RevMan 5.3 software.Results A total of 4 articles involving 438 patients were included.The results of meta-analysis showed that,the concentrations of HTAM and endoxifen in patients who had CYP2D6*10/*10 genotypes were lower than the other genotypes ( P<0.0001 ) .The concentration of tamoxifen in patients who had CYP2D6*10/*10 genotypes was lower than CYP2D6Wt/Wt ( P<0.05 ) .There was no significant difference between CYP2D6Wt/Wt and CYP2D6Wt/*10.Conclusion We concluded that CYP2D6 polymorphisms may influence concentrations of tamoxifen and its activity in Chinese breast cancer patients.
