Effect of endocrine hormone and cardiac function on patients with chronic heart failure by Huangqi Decoction
- VernacularTitle:中药黄芪水煎剂对慢性心衰患者内分泌激素及心功能影响研究
- Author:
Jing WANG
;
Haiwang GAO
;
Yueping LI
- Publication Type:Journal Article
- Keywords:
heart failure;
Huangqi Decoction;
neuroendocrine hormone;
ejection force
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):101-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse change of neuroendocrine hormone and cardiac ultra ejection force in patients with heart failure before and after treatment with Huangqi Decoction.Methods 100 patients diagnosed with chronic heart failure were collected.According to the different treatment regimens divided into two groups ( control group: conventional western medicine; traditional Chinese medicine group: conventional western medicine treatment +Astragalus Decoction orally for 2 weeks) , before and after treatment,nerve endocrine hormone using echocardiography evaluation index and ejection force were detected in two groups, and compare the results of data.Results Compared with control group, Chinese medicine group with better anti heart failure treatment, performance: the plasma calcitonin gene related peptide (CGRP), atrial natriuretic peptide (ANP), C type natriuretic peptide ( CNP ) , neuropeptide Y ( NPY ) levels were significantly lower ( P<0.05 ) . Capacity index significantly improved cardiac function (P<0.05).Left atrial diameter, left atrial maximum, minimum volume decreased significantly (P<0.05).Ejection force of left atrium and left ventricular increased significantly ( P<0.05 ) .The results were statistically significant.Conclusion Huangqi decoction can inhibit the secretion of CGRP, ANP, CNP,NPY and other neuroendocrine hormones in patients with heart failure, reduce cardiac load, increase cardiac ejection force.
