Influence of serum Bcl-2 and Bax in patients with myoma of uterus by Jiang Sanqi
- VernacularTitle:姜三七对子宫肌瘤患者血清中Bcl－2和Bax水平影响
- Author:
Jing XU
;
Liu YAGN
;
Wei NIE
- Publication Type:Journal Article
- Keywords:
Jiang Sanqi;
uterine myoma;
Bcl-2;
Bax
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):118-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect serum Bcl-2 and Bax in patients with myoma of uterus by Jiang Sanqi.Methods 92 patients with uterine fibroids were selected,and randomly divided into experiment group and control group.Control group of 46 cases treated with goserelin once 3.6 mg every month,subcutaneous injection,mifepristone 12.5 mg,once a day for oral treatment.Experiment group of 46 cases treated with Jiang Sanqi,0.5 g/kg,once a day for boiling water, for 3 months.The level of Bcl-2 and Bax in serum, clinical efficiency, diameter of tumor and complications were compared after treatment.Results The levels of Bcl-2 of experimental group patients was lower than control group, the level of Bax was higher than that of the control group (P<0.05).The total efficiency of experimental group(89.13%)was higher than that of the control group(71.74)%(P<0.05). The experimental group tumor diameter was smaller than the control group(P<0.05).Complications of the experiment was lower than the control group (P<0.05).Conclusion Jiang Sanqi can significantly reduce the serum Bcl-2 of patients with uterine fibroids,increase the expression level of Bax, reduce the uterine fibroids diameter effect, reduce the incidence rate of hormone suppression of drug side effects, has a great significance in clinical.
