Study on expression of TPS, VEGF of beast cancer patients and relationship with clinical pathological
- VernacularTitle:组织多肽特异性抗原与血管内皮生长因子与乳腺癌患者病理分级关系研究
- Author:
Daobao CHEN
;
Hongjian YANG
;
Bo CHEN
;
Xingfei YU
;
Weiliang FENG
- Publication Type:Journal Article
- Keywords:
tissue polypeptide specific antigen;
vascular endothelial growth factor;
breast cancer;
pathological features
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):121-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expression of TPS, VEGF of beast cancer patients and relationship with clinical pathological.Methods 68 cases of breast cancer were selected as experiment group, 36 cases with breast fibroma were selected as control group.TPS and VEGF were detected by elisa of patients before and after treatment.Serum TPS and VEGF levels and TNM staging were compared after operation.Results TPS and VEGF of the experiment group were higher than control group(P<0.05).TPS and VEGF of experiment group after operation were higher than before operation.TPS and VEGF increased with the grade of tumor, but there was no significance between grade Ⅰ and 0.The expression of VEGF in tumor diameter≤2 cm group was significantly lower than >2 cm group(P<0.05).TPS and VEGF of axillary lymph node metastasis group and axillary lymph node metastasis had significant difference(P<0.05).The concentration of TPS was significantly higher than that of estrogen and progesteronepositive group in estrogen receptor negative, progesterone receptor negative (P<0.05).Conclusion TPS, VEGF levels in the serum of breast cancer patients showed high expression, the expression of TPS, VEGF levels related to axillary lymph node metastasis, estrogen receptor, progesterone receptor.
