Study on effect of Xuebijing injection on Th1/2, endotoxin and immune factors in patients with acute sepsis
- VernacularTitle:血必净注射液对急性脓毒症患者Th1／2、内毒素及免疫因子影响研究
- Author:
Qin FANG
;
Gangjian JIANG
;
Xin CHEN
- Publication Type:Journal Article
- Keywords:
Xuebijing injection;
sepsis;
endotoxin;
specific immune function of spleen
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):130-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of Xuebijing injection on Th1/2, endotoxin and immune factors in patients with acute sepsis.Methods 110 cases of sepsis patients were selected and divided into two groups from September 2014 to January 2015.The control group of 55 cases were treated by clinical routine therapy, the experiment group of 55 cases were treated with Xuebijing injection on the basis of control group.Hemodynamics, serum Th1/2, endotoxin and specific immunological function of spleen were compared.Results After treatment, the heart rate of experiment group was significantly lower than control group (P<0.05), the mean arterial pressure and central venous pressure were higher than control group (P<0.05), vasoconstrictive drugs application amount was less than control group ( P<0.05 ) , the ratio of Th1/Th2 was higher than control group ( P<0.05 ) , serum endotoxin levels was lower than control group (P<0.05), and the ratio of HLA-DR, lymphocyte proliferation and positive index of caspase-3 cells were lower than control group(P<0.05).Conclusion Xuebijing injection can effectively improve haemodynamics in patients with sepsis, regulate serum Th1/Th2 levels, reduce serum endotoxin level and enhance specific immune function of spleen, which has important significance for clinical treatment of sepsis.
