Effect of mouse nerve growth factor on humoral immunity in children with severe hand foot mouth disease

VernacularTitle:鼠神经生长因子对危重型小儿手足口病患者体液免疫的影响
Author: Chuanying HAN ; Gangjian JIANG ; Xin CHEN
Publication Type:Journal Article
Keywords: mouse nerve growth factor; severe hand foot mouth disease; humoral immunity; prognosis
From: Chinese Journal of Biochemical Pharmaceutics 2015;37(5):134-136
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of mouse nerve growth factor on humoral immunity in children with severe hand foot mouth disease. Methods 92 patients with severe hand foot mouth disease were selected from June 2010 to September 2012 in the hospital, and randomly divided into two groups.The indexes of blood cell analysis, humoral immunity, cytokines and T lymphocyte subsets were compared after treatment.Results After treatment, compared with control group, the numeration white blood cell, neutrophil and lymphocyte of observation group were lower (P<0.05), IgM, IgG and IgA were higher (P<0.05), IL-1, IL-6 and IL-10 were lower (P<0.05), CD4 +and CD8 +were higher (P<0.05).Conclusion Mouse nerve growth factor can significantly improve the each index of humoral immunity cytokines and T lymphocyte subsets level in children with hand foot mouth disease, which has the great significance in clinical.