Integrator complex and its research progress
10.7644/j.issn.1674-9960.2015.05.019
- VernacularTitle:整合因子复合体研究进展
- Author:
Lanlan SI
;
Hongxing ZHANG
;
Gangqiao ZHOU
- Publication Type:Journal Article
- Keywords:
integrator complex;
RNA polymeraseⅡ;
snRNA;
mRNA transcription
- From:
Military Medical Sciences
2015;(5):398-402
- CountryChina
- Language:Chinese
-
Abstract:
The integrator complex is multifunctional and contains at least 12 evolutionarily conserved subunits in hu-mans.It interacts with the C-terminal tail of the largest subunit of RNA-polymeraseⅡ ( RNAPⅡ) to promote 3′-end pro-cessing of small nuclear RNA (snRNA) U1/U2.It also interacts with RNAPⅡ, NELF and Spt5 to regulate NELF-mediated RNAPⅡpause/release and processivity at coding genes .Recently, the integrator complex is also reported to be involved in DNA damage response , dynein recruitment to the nuclear envelope , integrity of Cajal bodies , adipose differentiation , hem-atopoiesis , ciliogenesis , tumorigenesis and generation of viral microRNAs .This review discusses related research progress in the integrator complex .
