Impact of colorectal cancer laparoscopic and open surgery on immune function
10.3969/j.issn.1000-484X.2015.05.020
- VernacularTitle:结直肠癌腹腔镜与开腹手术对免疫功能的影响分析
- Author:
Wenbo NIU
;
Chaoxi ZHOU
;
Juan ZHANG
;
Guangquan AN
;
Yueming YU
;
Guiying WANG
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Laparoscopy;
Laparotomy;
Immune function
- From:
Chinese Journal of Immunology
2015;(5):670-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the impact of colorectal cancer laparoscopic and open surgery on immune function.Methods:85 patients from January 2010 to December 2013 due to surgical treatment of colorectal cancer hospitalized in our department were randomly divided into experimental and control groups.The experimental group underwent laparoscopic surgery, the control group underwent laparotomy.The peripheral blood lymphocyte subsets, immunoglobulins, CRP and IL-6 levels, NO and ROS levels were compared in two groups of patients before and after one day,seven days of surgery.Results: The postoperative CD3,CD4,CD4/CD8 level after one day and seven days of surgery was significantly lower than before surgery, CD8 was significantly higher than before surgery,P<0.05.The postoperative CD3, CD4, CD4/CD8 level after one day and seven days in the experimental group were significantly higher,CD8 was significantly lower than the control group,P<0.05.The postoperative IL-6,CRP levels after one day and seven days of surgery were significantly higher than before surgery,IgG,IgM and IgA were significantly lower than before surgery,P<0.05.The postoperative IL-6,CRP levels after one day and seven days of surgery in the experimental group were significantly lower than the control group,IgG,IgM and IgA were significantly higher,P<0.05.The NO and ROS levels after one day and seven days of surgery in the control group were significantly higher than the preoperative and postoperative period the experimental group,P<0.05.The NO and ROS levels after one day and seven days of surgery in the experimental group were no significant difference,P>0.05.Conclusion:Compared to open surgery,laparoscopic treatment of colorectal cancer has a protective and smaller effect for the body′s immune func-tion.
