Meta-analysis of disodium cantharidinate injection combined with transcatheter arterial chemoembolization in the treatmemt of hepatocellular carcinoma
- VernacularTitle:斑蝥酸钠注射液联合肝动脉化疗栓塞术治疗原发性肝癌的Meta分析
- Author:
Zhong XU
;
Hui CAO
;
Banjun BAI
- Publication Type:Journal Article
- Keywords:
disodium cantharidinate injection;
hepatocellular carcinoma;
TACE;
randomized controlled trial;
Meta-analysis
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):66-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of disodium cantharidinate injection combined with transcatheter arterial chemoembolization(TACE) compared with TCAE alone in the treatment of hepatocellular carcinoma(HCC) by meta-analysis.Methods Databases of Pubmed, CNKI,Wangfang and VIP were searched electronically, and the randomized controlled trials about disodium cantharidinate injection combined with TACE in the treatment of HCC were included.Meta-analyses were conducted after the quality of the included studies was assessed.Results Seven eligible studies that included a total of 562 HCC patients were identified in the present meta-analysis.The combined results showed that disodium cantharidinate injection combined with TACE in the treatment of HCC, compared with TACE alone, could increase effective rate ( RR =1.31, 95%CI 1.10-1.56) and clinical benefit rate (RR =1.20, 95%CI 1.04 -1.39), improve the life quality (RR =1.60, 95%CI 1.26 -2.03) and improved the 1, 2 year survival (RR =1.57 with 95%CI 1.28 -1.93 and RR =2.08 with 95%CI 1.46 -2.97, respectively).Conclusion Meta-analysis indicates that the efficacy of disodium cantharidinate injection combined with TACE is superior to TACE alone for the patients with HCC.
