Evidence-based evaluation of the effect of mouse nerve growth factor on fracture healing
- VernacularTitle:鼠神经生长因子对骨折愈合影响的循证评价
- Author:
Hongliang ZHANG
;
Zhenguang HUANG
;
Yan WEN
;
Shuangyi TANG
;
Taotao LIU
- Publication Type:Journal Article
- Keywords:
mouse nerve growth factor;
fracture;
GRADE;
evidence-based evaluation;
Meta-analysis
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of mouse nerve growth factor on fracture healing.Methods Cochrane library, Pubmed, EMbase, CNKI,VIP,Wanfang Data and CBM were searched for the randomized controlled trials(RCTs)of mouse nerve growth factor on fracture healing from the date of establishment of the databases to May 2014.Three independent rese archers evaluated the included studies using GRADE,according to recommend classification method of GRADE system by three researchers,crtical evaluated and data extracted of the quality of the included studies,which conform to the quality standard of RCT was analyzed by Meta analysis.The extracted data were analyzed by RevMan 5.0 and GRAED proiler.Results A total 5 trials were discovered and all of these were in Chinese.Compared with conventional treatment was improved a lot[MD =-8.74,95%CI( -9.79,-7.68),P<0.0001].However, adverse drug reaction in patients with mouse nerve growth factor were increased[OR =14.66,95%CI(1.89, 113.99),P=0.01].The both outcomes were low quality in the GRADE system.Conclusion Mouse nerve growth factor can improve fracture healing and the side effects will also increase.
