Study on effect of serum apoptosis factor and long-term effect on medical abortion patients by sequential misoprostol
- VernacularTitle:米索前列醇的序贯疗法对药流患者血清凋亡因子及远期疗效的影响研究
- Author:
Xia LI
;
Jun WANG
;
Yue WANG
;
Yan GUO
;
Xiaocai WANG
- Publication Type:Journal Article
- Keywords:
misoprostol;
early pregnancy;
survivin;
caspase-3
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):112-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of serum apoptosis factor and long-term effect on medical abortion patients by sequential misoprostol. Methods 80 cases of early pregnancy patients who required termination pregnancy, were selected and randomly divided into 2 groups.40 cases in control group were treated with mifepristone 25mg oral, misoprostol 600μg, 4 times a day.40 cases in experiment group were treated with sequential use of misoprostol.Effect of medical abortion, survivin and caspase-3 were compared after 7d treatment.Gynecological inflammation, dysmenorrhea and infertility were compared for 2 years.Results Compared with control group, complete abortion rate of the experiment group was higher (P<0.05).The incidence of adverse drug reactions of the experiment group was lower than control group (P<0.05) after 2 years follow.up.Compared with the control group, HCG,E3 and P of experimental group were lower (P<0.05).After 7 days of medication,survivin decreased,caspase-3 increased,compared with control group, survivin of the experiment group was lower, caspase-3 was higher ( P<0.05 ) .Conclusion Misoprostol sequential can improve the success rate of medical abortion abortion, reduce the complications of abortion, presumably with the inhibition of survivin expression, is associated up regulation of caspase-3 levels.
