Study on antioxidant of ethyl polyenoate soft capsules
- VernacularTitle:多烯酸乙酯软胶囊的抗氧化剂研究
- Author:
Liping REN
;
Juan LIN
;
Qi MIN
;
Haiming LIAO
;
Hongmiao YANG
;
Huihong FAN
- Publication Type:Journal Article
- Keywords:
ethyl polyenoate soft capsules;
antioxidant;
antioxidation effect;
vitamin E;
α-tocopherol;
tocopherol acetate
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):174-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze peroxide value and anisidine value of ethyl polyenoate soft capsules and imported drugs and evaluate the oxidative stability.Methods The analysis was carried out on a TSK gel ODS-100 V(250 mm ×4.6 mm,5μm)with methanol-water(98:2,V/V)as the mobile phase to determine the structure of the vitamin E as antioxidant.The influence on the antioxidation effect of tocopherol acetate andα-tocopherol as excipient in omega-3 polyunsaturated fatty acid ethyl ester drugs was evaluated.Results The structure of vitamin E as antioxidant in domestic drugs was acetate, while vitamin E as excipient in foreign drugs had the structure of α-tocopherol monomer.As antioxidant, the antioxidation effect of tocopherol acetate was better thanα-tocopherol.The structure of vitamin E had a direct impact on the antioxidation effect of omega-3 polyunsaturated fatty acid ethyl ester drugs.Conclusion The studies provide the basis for evaluate rationality of antioxidant in ethyl polyenoate soft capsules scientifically, which has positive significance for controlling the quality of the drug effectively.
