Research of Treg and cytokines in patients with hepatitis B virus infection
10.3969/j.issn.1673-4130.2015.10.011
- VernacularTitle:HBV感染者调节性T淋巴细胞与细胞因子研究
- Author:
Xiaoxia YAN
;
Xilian CHEN
;
Caidong LI
;
Bin WU
;
Zhengjun DUAN
;
Pengfei TIAN
- Publication Type:Journal Article
- Keywords:
viral hepatitis type B;
T regulatory cells;
cytokines;
hepatitis Be antigen
- From:
International Journal of Laboratory Medicine
2015;(10):1346-1348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value and clinical significance of CD4+CD25+ regulatory T cells (Treg) ,inteleukin‐18 , interferon‐γand transforming growth factor‐βin patients with hepatitis B virus (HBV) infection .Methods A total of 175 patients with HBV infection were divided into chronic type B hepatitis (CHB) group and chronic asympotomatic HBV carrier (ASC) group , which were further divided into hepatitis B e antigen (HBeAg) positive and negative groups .CD4+ CD25+ Treg ,cytokines levels and liver function were measured .Healthy subjects were enrolled into control group .Results Proportion of CD4+CD25+ Treg were without significant difference among healthy controls ,HBeAg(+ ) and HBeAg(-) ASC groups ,and HBeAg(+ ) and HBeAg(-) CHB groups (P>0 .05) .Compared with control group ,cytokines levels were significant higer in CHB and ASC group (P<0 .05) . CD4+CD25+ Treg level was significant positive correlation to alanine aminotransferase and ratio of aspartate aminotransferase to plateles in HBeAg(+ )ASC group (P<0 .05) .Conclusion CD4+CD25 + Treg and related cytokines could play important roles in the course of CHB ,while CD4+CD25+ Treg expressing might be correlated with inflammatory degree of hepatitis .
