Clinical significance of IL-1β,IL-8 and TNF-αexpression in patients with acute cerebral infarction
10.3969/j.issn.1673-4130.2015.10.044
- VernacularTitle:急性脑梗死患者血清IL-1β、IL-8及TNF-α的临床意义
- Author:
Xin LING
- Publication Type:Journal Article
- Keywords:
acute cerebral infarction;
interleukin;
tumor necrosis factor-α
- From:
International Journal of Laboratory Medicine
2015;(10):1419-1420
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and clinical significance of the serum concentrations of serum IL‐1β,IL‐8 and TNF‐αin patients with acute cerebral infarction .Methods Serum concentrations of IL‐1β,IL‐8 and TNF‐αfrom 187 patients with acute cerebral infarction and 150 healthy donors were determined by enzyme linked immunosorbent assay (ELISA) .Results The serum levels of IL‐1β,IL‐8 and TNF‐αwere markedly higher in the 3 different infarct size subgroups than in the control group ,and the 3 indexes were statistically increased with increasing infarct size .Conclusion Serum levels of IL‐1β,IL‐8 and TNF‐αincreased markedly in patients with acute cerebral infarction ,which was closely related to infarct size ,and could be used as the indicators for severity assessment ,therapy monitoring and prognosis judgement in acute cerebral infarction patients .
