Correlation of microvascular characteristics under narrow band imaging with MVD, IGF-1, and STAT3 expression during cancer-ization of colorectal polyp
10.3969/j.issn.1000-8179.20150270
- VernacularTitle:结肠息肉癌变过程中内镜微血管特征与MVD IGF-1 STAT3表达相关性研究
- Author:
Hong LIU
;
Jing WU
;
Xiangchun LIN
;
Kuiliang LIU
;
Yanhui MA
;
Ruijin YU
- Publication Type:Journal Article
- Keywords:
narrow band imaging;
colorectal adenoma;
early colorectal carcinoma;
microvascular pattern;
tumor angiogenesis
- From:
Chinese Journal of Clinical Oncology
2015;(10):499-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the expression of angiogenic factors (MVD, IGF-1, and STAT3) in colorectal carcinoma and adenoma and the microvascular characteristics under narrow band imaging (NBI), in order to evaluate the fea-sibility of NBI in real-time observation of angiogenesis. Methods:Patients with pathologically confirmed colorectal polyps were re-cruited and examined by NBI. Vascular patterns were classified into typeⅠ(invisible or faintly visible), typeⅡ(clearly visible and regularly arranged in a round, oval honeycomb-like pattern), and typeⅢ(clearly visible and irregularly arranged in terms of size and caliber or irregularly winded). Immunohistochemical staining was performed to determine the expression of CD34, IGF-1, and STAT3. Histological results were compared with the vascular patterns under NBI. Results:The NBI endoscopy results of 64 sites (15 adenocar-cinomas, 29 adenomas, and 20 normal tissues) from 58 patients were introduced and examined in this study. Adenomas ranked the first (82.1%, 23/28) among the vascular patternⅡcases, whereas early adenocarcinomas dominated the vascular patternⅢcases (66.7%, 10/15). The expression levels of MVD-CD34 and IGF-1 in normal mucosa, adenomas, and adenocarcinomas were significantly differ-ent (P<0.0001 and P=0.0062, respectively). All the expression levels of MVD-CD34, IGF-1, and STAT3 in sites displaying vascular pat-ternsⅠ,Ⅱ, andⅢwere significantly different (P<0.0001, P=0.0010, and P=0.0055, respectively). Spearman correlation coefficients between the NBI vascular patterns and the MVD-CD34, IGF-1, and STAT3 expression levels were 0.67, 0.41, and 0.40, respectively. Conclusion:Vascular pattern analysis through an NBI system can be a promising tool to evaluate angiogenesis of colorectal lesions in real-time endoscopic observation.
