Analyses of treatment outcomes and prognostic factors for occult breast cancer
10.3969/j.issn.1000-8179.20150234
- VernacularTitle:隐匿性乳腺癌的治疗选择及预后因素分析
- Author:
Xue YANG
;
Jing WANG
;
Yefan ZHANG
;
Xiangyu WANG
;
Yi FANG
- Publication Type:Journal Article
- Keywords:
occult breast carcinoma;
surgery;
radiotherapy;
target therapy;
prognosis
- From:
Chinese Journal of Clinical Oncology
2015;(10):509-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Occult breast cancer (OBC) accounts for 0.3%-1.0%of all breast cancers. Because of the rarity of this dis-ease, its treatment and prognosis remain unclear. Our study evaluated the treatment outcomes and prognostic factors associated with OBC. Methods:A total of 82 patients diagnosed with OBC based on available criteria were treated at the Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China, between January 1968 and June 2014. Except for 16 patients who were treated by needle biopsy or excisional biopsy only and were subsequently excluded, all of the cases reported were included in the study. Of the remaining 66 patients, one was male. Patient data, tumor characteristics, and treatment and outcome variables were evaluated. Overall survival (OS) and disease-free survival (DFS) were analyzed. A unicentric retrospective review of 66 patients with OBC was performed. Re-sults:The median follow-up was 75.5 months (7.0-328.0). No significant differences in OS and DFS were observed between patients who underwent mastectomy plus axillary lymph node dissection (Mast+ALND) and those who underwent breast conservation surgery (P>0.05). Univariate analysis revealed that nodal status is a significant prognosis factor of DFS (P=0.031). Conclusion:No significant difference in treatment outcomes between mastectomy+ALND and breast conservation surgery was observed. Nodal status may be an independent predictor of poor outcomes in OBC patients.
