Different acoustic power of high-intensity focused ultrasound for the treatment of human pancreatic xenograft tumor:preliminary experimental study
10.3969/j.issn.1008-794X.2015.07.013
- VernacularTitle:不同功率高强度聚焦超声治疗人胰腺癌移植瘤初步实验研究
- Author:
Lili HONG
;
Zhi GUO
;
Wenge XING
;
Shaoshan WANG
;
Xueling YANG
;
Hailong WANG
- Publication Type:Journal Article
- Keywords:
high-intensity focused ultrasound;
pancreatic cancer;
apoptosis
- From:
Journal of Interventional Radiology
2015;(7):612-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of different acoustic power of high-intensity focused ultrasound (HIFU) in treating human pancreatic xenograft models. Methods Human pancreatic cancer cells (YY-1) were implanted subcutaneously in nude mice to establish animal models. The tumor bearing mice were divided into low-power HIFU treatment group (200 W,n=10), high-power HIFU treatment group (300 W,n=10) and blank control group (n=10). The change of tumor volume, the tumor growth rate and side effects were recorded. The apoptosis rate of tumor cells of each group was determined by TUNEL method. Results The tumor volume and the tumor growth rate of the low-power group and the high-power group were significantly lower than those of the control group (P<0.05), while no statistically significant differences in the tumor volume and the tumor growth rate existed between the low-power group and the high-power group (P>0.05). Compared with the low-power group, the incidence of side effects in the high-power group was significantly higher (P<0.05), including mainly skin burn (60%) and acoustic channel injury (20%). At the 7th and 14th day after the treatment, the apoptosis rates of tumor cells in both the low-power group and the high-power group were significantly higher than that of the control group (P<0.05), but the difference in the apoptosis rates of tumor cells was not statistically significant between the low-power group and the high-power group (P>0.05). Conclusion For the treatment of human pancreatic xenograft tumor in nude mice models, HIFU with low power is effective and safer.
