Clinical Efficacy of Three Kinds of Topical Drug on Preventing Peripheral Chemotherapeutic Phlebitis Caused by Continuous Infusion of 5-fluorouracil
- VernacularTitle:三种外用药物预防5-氟尿嘧啶持续泵入所致外周化疗性静脉炎的临床效果
- Author:
Ling YU
;
Guichun JIANG
;
Lanruo SU
;
Jing HUANG
- Publication Type:Journal Article
- Keywords:
chemotherapy phlebitis;
prevention;
Hiru doid;
Sufu;
Musk Hemorrhoids Ointment
- From:
Journal of China Medical University
2015;(7):610-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Hiru doid,Sufu and Musk Hemorrhoids Ointment on preventing peripheral chemothera?peutic phlebitis due to continuous infusion of 5?fluorouracil. Methods Totally 90 patients with esophageal squamous cell carcinoma treated with continuous infusion of 5?fluorouracil were recruited and randomly divided into Hirudoid group,Sufu group and Musk Hemorrhoids Ointment group, with 30 cases in each group. Three groups were applied with drugs respectively along the vein punctured while connecting the pump of 5?fluorouracil 3 times a day(each time interval of 6 hours)for 5 consecutive days. The occurrence of chemotherapy phlebitis was observed and recorded. Results Musk Hemorrhoids Ointment and Sufu were more effective than Hirudoid in reducing the incidence of phlebitis and relieving the degree of venous in?jury(P<0.05);however,there were no differences between Musk Hemorrhoids Ointment and Sufu(P>0.05). Musk Hemorrhoids Ointment was the most effective among the three in relieving the pain caused by phlebitis(P<0.05). There were no difference between Sufu and Hirudoid(P>0.05). Conclusion Musk Hemorrhoids Ointment can effectively prevent peripheral chemotherapeutic phlebitis caused by continuous infusion of 5?fluorouracil with affordable expense which is worthy of promotion in clinic use.
