Protective effects of limb remote ischemic postconditionting on ischemic stroke rats under hyperglycemia

VernacularTitle:肢体后适应对高糖状态下大鼠脑缺血/再灌注损伤的保护作用
Author: Gangling CHEN ; Lanxi XU ; Huan ZHAO ; Xiaoying WU ; Lingling CHAI ; Donglin ZENG ; Qi WU
Publication Type:Journal Article
Keywords: limb remote ischemia-postconditioning; acute hyperglycemia; ischemia-reperfusion injury; SOD; NO; rat
From: Chinese Pharmacological Bulletin 2015;(6):780-784
CountryChina
Language:Chinese
Abstract: Aim To study the protective effects of limb remote ischemic postconditioning ( LRIP ) on is-chemic stroke rats under hyperglycemia and explore the mechanisms. Methods Rats were given 50% glucose (6 mL·kg-1 ) by intraperitoneal injection to get acute hyperglycemia model. Then middle cerebral artery oc-clusion ( MCAO) models were created. After blocking middle artery for 1. 5 h and reperfusion for 2 h, behav-ioral testing, infarct size of brain, NO concentration and SOD activity in the serum of those rats were detec- ted. Results LRIP could improve behavioral score, decrease the area of cerebral infarction, increase the concentration of NO and the SOD activity in serum of MCAO rats. Conclusion LRIP can relieve cerebral ischemia-reperfusion injury of MCAO rats under acute hyperglycemia.