Expression of HLA-G in ovarian serous carcinoma and its clinical significance

VernacularTitle:卵巢浆液性癌中HLA-G的表达及临床意义
Author: Wei WEI ; Bo YU ; Rusong ZHANG ; Zhenfeng LU ; Jiandong WANG ; Qunli SHI
Publication Type:Journal Article
Keywords: ovarian neoplasm; serous carcinoma; HLA-G; immunohistochemistry; prognosis
From: Chinese Journal of Clinical and Experimental Pathology 2015;(5):488-491
CountryChina
Language:Chinese
Abstract: Purpose To investigate the expression and significance of HLA-G in ovarian serous carcinoma ( OSC) . Methods HLA-G antigen was immunohistochemically labeled on paraffin-embedded sections of 108 OSCs. The relationship between HLA-G expression and the clinicopathologic parameters was studied. Results The positive expression of HLA-G was observed in 58. 33% (63/108) of OSC tissues. Positive expression of HLA-G was significantly related with lymph node metastasis, recurrence, occurrence site, FIGO stage and MDACC grading system (P<0. 05). In survival analysis, the expression of HLA-G was significantly relevant to prognosis (P=0. 015). Multivariate Cox analysis showed the expression of HLA-G was an important prognosis factor of OSC (P=0. 01). Con-clusion The positive expression of HLA-G could predict high grade and advanced stage of OSC as well as poor prognosis. Also it could distinguish high-grade OSC from low-grade OSC.