Relationship between ROS, PI3K/AKT signaling pathways associated protein and prostate cancer angiogenesis
10.13315/j.cnki.cjcep.2015.05.016
- VernacularTitle:前列腺癌新生血管生成与ROS和PI3 K/AKT信号通路相关蛋白的关系
- Author:
Zhongying GUO
;
Guangbo FU
;
Haiyan LIU
;
Suan SUN
- Publication Type:Journal Article
- Keywords:
prostate neoplasm;
reactive oxygen species;
p70S6K1;
tumor angiogenesis
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(5):552-555
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of reactive oxygen species (ROS) and PI3K/AKT signaling pathway associated gene protein p70S6K1, VEGF in prostate cancer and adjacent tissues, and to determine their relationship with micro-vascular density ( MVD) , as well as the relationship between themselves. Methods The expression of ROS was detected by immunofluorescence, and the expression of p70S6K1, VEGF and MVD counting were detected by immunohistochemistry. Results Compared to adjacent tis-sues, the expression of ROS, p70S6K1, VEGF and MVD in PCa were increased considerablely (P<0. 05). In prostate cancer the ex-pression of ROS were positively correlated to the expression of p70S6K1, VEGF protein, and the expression of ROS and p70S6K1, VEGF were positively correlated to the number of MVD. Conclusion (1)The expression level of ROS in prostate cancer tissues was significantly higher than adjacent tissues. (2) The expression of PI3K/AKT pathway associated gene protein p70S6K1, VEGF protein and MVD counting in prostate cancer tissue was higher than the adjacent tissues, suggesting PI3K/AKT signaling pathways may play a role in tumor angiogenesis. (3) The expression of ROS and PI3K/AKT pathway associated gene protein p70S6K1, VEGF and MVD counting in prostate cancer tissues was positively correlated, suggesting that ROS may play a positive regulatory role for the development of prostate cancer by PI3K/AKT signaling pathway.
