Chronic colitis induced by irritant dextran sodium sulphate promote hepatoma development in mice
10.3969/j.issn.1671.7856.2015.005.001
- VernacularTitle:慢性肠道炎症促进肝癌的发展
- Author:
Honggan YI
;
Mengya ZANG
;
Zhiyuan WU
;
Zheng ZHU
;
Xinming ZHAO
;
Weihu WANG
;
Chunfeng QU
- Publication Type:Journal Article
- Keywords:
Chronic colitis;
Liver cancer;
Gut bacteria
- From:
Chinese Journal of Comparative Medicine
2015;(5):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of gut bacteria under chronic colitis on the progression of hepatoma in mice.Methods 22 hepatitis B virus (HBV) -transgenic mice ( male, 8 weeks) were randomly divided into two groups, one group (n =10) was fed the drinking water containing 2% dextran sodium sulphate(DSS)to induce chronic colitis and the control group(n =12)was fed with normal drinking water.In order to investigate the effect of gut microbes, 7 male HBV-transgenic mice(8 weeks, with no detectable hepatoma under microscopy) were cohoused with 4 mice with hepatoma for 16 weeks.Results No significant liver cell damage was observed in the group of the mice fed with 2% DSS-containing drinking water.By the 22 -week old,9 of the 10 mice(90.0%) fed with 2% DSS-containing drinking water, 2 of the 12 mice(16.7%) fed with normal drinking had hepatoma.Both the hepatoma incidence and the tumor numbers in the group of mice fed with DSS-containing water were significantly higher than that in the controls (P =0.002 and P =0.028respetively).Compared to controls, the bacteria family Prevotella (P =0.022) and Anaeroplasma (P =0.014) reduced significantly in the mice with induced chronic colitis.All the mice (n =7) cohoused with the mice with hepatoma had the liver tumor developed at 24 -week-old.Conclusion Alterations of gut bacteria under chronic colitis may promote the development of liver cancer.
