Detection of Focal Liver Lesions with Diffusion Weighted Imaging:Results of A Multi-center Clinical Trial
10.3969/j.issn.1005-5185.2015.05.009
- VernacularTitle:扩散加权成像对肝局灶病变检出的多中心研究
- Author:
Xiaoqiang LI
;
Xun YAO
;
Dawei YANG
;
Xinkun WANG
;
Huiyi YE
;
Tao JIANG
;
Zhenghan YANG
- Publication Type:Journal Article
- Keywords:
Liver diseases;
Diffusion magnetic resonance imaging;
Diffusion weighted imaging;
Multicenter study
- From:
Chinese Journal of Medical Imaging
2015;(5):356-360
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo investigate the role of diffusion weighted imaging (DWI) in the detection of focal liver lesions (FLL).Materials and Methods T2WI, dynamic contrast enhancement (DCE) and DWI (b=100 s/mm2 and 600 s/mm2 respectively) were performed in 205 patients with 310 FLLs. All images were read by two reviewers to determine the detection of FLLs and score the confidence. The consistency of the results given by the two reviewers was evaluated. The confidence scores between different sequences and the detection rate of different sequences were also compared.Results The consistency of the two reviewers was excellent or good in T2WI, high b value DWI, low b value DWI, and DCE (Kappa=0.71, 0.85, 0.82 and 0.64,P<0.05). As to the confidence score of lesion detection, high b value DWI and low b value DWI were both significantly higher than T2WI (P<0.01), but both were lower than DCE (P<0.01). DWI yielded higher score and detection rate for detecting FLLs than T2WI (86.5%vs. 70.3%,P<0.01), but lower than DCE (91.6%,P<0.05). For small malignant lesions (≤2 cm in diameter), DWI showed similar detection rate with DCE (P>0.05), but higher than T2WI (P<0.01). The combination of DWI and DCE detected more small malignant lesions than DWI or DCE alone (P<0.01).Conclusion DWI can detect more FLLs than T2WI, and can help DCE detect small malignant FLLs. Therefore DWI is suggested to be included in the routine protocol of liver MRI examination.
