Expression of p16 and TLR3 in cervical intraepithelial neoplasia and cervical invasive carci-noma and their significance
10.13315/j.cnki.cjcep.2015.05.005
- VernacularTitle:子宫颈上皮内瘤变及子宫颈癌组织中 p16和 TLR3的表达及意义
- Author:
Yuwen GUO
;
Zhengsheng WU
;
Heping ZHANG
;
Xinrong TAO
- Publication Type:Journal Article
- Keywords:
cervical neoplasm;
cervical intraepithelial neoplasia;
p16;
TLR3
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(5):502-505
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression and clinical significance of the cell cycle inhibitors p16 protein and specific recogni-tion of viral replication intermediate TLR3 in the cervical intraepithelial neoplasia ( CIN) and cervical invasive carcinoma. Methods Immunohistochemical stain was used to detect the expressions of p16 and TLR3 in 19 cases of normal cervical epithelium ( NCE) , 62 cases of CIN, and 17 cases of cervical squamous cell carcinoma (SCC). Results The positive rates of p16 protein were 0, 72. 5%and 100% in NCE, CIN and SCC respectively in which the difference among those groups were statistically significant ( P<0. 01 ) . Similarly, the positive rates of TLR3 protein were 26. 3%, 87% and 100% in NCE, CIN and SCC respectively and the difference a-mong those groups was significant (P<0. 01). Furthermore, there was a significant and positive correlation between the expression of p16 and TLR3 (rs =0. 538, P<0. 01). Conclusion Increased expression is observed in CIN and SCC compared with NCE and the expression of p16 and TLR3 is associated with level of CIN. Those could provide certain experiment basis for the pathologica diagnosis of early cervical cancer.
