Antimicrobial susceptibility of 9 strains of carbapenemase-producing Klebsiella pneumoniae
- VernacularTitle:产KPC酶肺炎克雷伯菌9株的药敏试验结果分析
- Author:
Ying JIN
;
Junfang WANG
;
Jiqin LIU
;
Xin ZHOU
- Publication Type:Journal Article
- Keywords:
K lebsiella pneumoniae;
carbapenemase;
antimicrobial resistance;
tigecycline
- From:
Chinese Journal of Infection and Chemotherapy
2015;(3):257-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the resistant profile and genotypes ,as well as susceptibility to tigecycline in carbapenemase‐producing K lebsiella pneumoniae for better clinical management of such infections .Methods Nine strains of carbapenemase‐producing K .pneumoniae were isolated from clinical specimens during the period from February 2012 to May 2013 in our hospital .Bacterial identification and antimicrobial susceptibility testing were carried out with VITEK 2 Compact automatic microbiological assay systems .The phenotype of carbapenemase‐producing K . pneumoniae was detected by modified Hodges test .The genotype of carbapenemase was identified by PCR method .The susceptibility to tigecycline was tested by E‐test . Results All the 9 strains of carbapenemase‐producing K . pneumoniae were resistant to the 19 antibiotics tested .Modified Hodges test was positive for 7 strains (77 .8% ) .Target band of carbapenemase gene was identified in all the 9 strains of K . pneumoniae ,and all were confirmed as KPC‐2 gene .All the 9 strains were susceptible to tigecycline .Conclusions The resistance of carbapenemase‐producing K .pneumoniae is still serious .Tigecycline has shown good in vitro activity against such strains .
