Neutrophil CD64 guidance of antibiotic therapy in severe pneumonia
10.3760/cma.j.issn.1008-6706.2015.10.010
- VernacularTitle:中性粒细胞 CD64对重症肺炎抗生素疗程的指导价值
- Author:
Miaomiao CHEN
;
Yiping NING
;
Tianzheng LOU
;
Junlong XU
;
Ning ZHANG
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
Pneumonia;
Neutrophil CD64;
Antibiotic;
Intensive Care Unit
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(10):1471-1474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of neutrophil CD64 positive cells percentage(CD64%)detec-tion to stop using antibiotic in patients with severe pneumonia.Methods 60 accepted antibiotic therapy patients with severe pneumonia,in accordance with the random number table,were separated into observation group(n =30)and control group(n =30).Antibiotics were stopped according to CD64% in observation group,while it according to the clinical symptoms,the plasma level of white blood cell and C -reactive protein in control group.The main observation indexes included the days of antibiotics use,the length of Intensive Care Unit(ICU)stay,clinical efficacy and the case fatality rate.Results The days of antibiotics use in the observation group was (10.3 ±5.2)d,while it was (16.8 ± 5.8)d for patients in the control group,and it had significant difference(t =-4.570,P <0.01).The length of ICU stay in the observation group was shorter than that in the control group[(6.5 ±3.5)d vs (10.5 ±4.5)d],and it had significant difference(t =3.843,P <0.01).The clinical efficacy were 83.67% and 82.12%,and the case fatality rate were 9.68% and 10.24% in the observation group and control group,respectively,and both had no significant difference(P >0.05).Conclusion Stop using antibiotics according to the neutrophil CD64 % is safe,reliable,and can effectively reduce the excessive use of antibiotics and shorten the length of ICU stay in patients with severe pneumonia.
