Effect of micro ecological preparation on imbalance of intestinal flora in pediatric blood cancer after chemo-therapy
10.3760/cma.j.issn.1008-6706.2015.10.014
- VernacularTitle:微生态制剂对小儿血液肿瘤化疗后肠道菌群失调的影响
- Author:
Shanping ZHENG
;
Changfu ZHENG
- Publication Type:Journal Article
- Keywords:
Hematologic Neoplasms;
Enterobacteriaceae;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(10):1484-1486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of micro ecological preparation on imbalance of intestinal flora in pediatric blood cancer after chemotherapy.Methods The clinical data of 60 patients with blood cancer were retrospectively analyzed.All patients were divided into the observation group and control group by different trentment methods,30 cases in each group.The control group were received conventional chemotherapy,the observation group were given Lactobacillus triple viable Bifidobacterium piece(two piece once,tid,4 weeks for a course)on the basis of the control group,the intestinal flora(Enterobacteriaceae,Enterococcus,Bifidobacterium,Lactobacillus,Escherichia coli)were detected before and after chemotherapy,made a record of respiratory,urinary,digestive,skin infections after chemotherapy.Results The Bifidobacterium and Lactobacillus of the observation group after treatment were signifi-cantly higher than before treatment(t =3.947,3.636,all P <0.05),there were no difference in Enterobacter,Entero-coccus,Escherichia coli in the observation group before and after treatment(all P >0.05).The Enterobacter,Entero-coccus,Bifidobacterium,Lactobacillus,Escherichia coli of the control group were lower after treatment than before treatment(t =3.712,3.641,3.722,3.543,3.616,all P <0.05),the Enterobacter,Enterococcus,Bifidobacterium, Lactobacillus,Escherichia coli of the observation group after treatment were higher than that of the control group(t =3.327,3.641,6.378,7.367,3.364,all P <0.05).The respiratory tract infection,cholecystitis,colitis,urinary tract infections incidence of the observation group were 50.00%,6.67%,16.67%,23.33%,respectively,which were low-er than 93.33%,30.00%,63.33%,60.00% of the control group(χ2 =13.871,5.455,13.611,8.297,all P <0.05).Conclusion The intestinal flora may be caused for treatment of chemotherapy,which are the importmant rea-son of various infections after chemotherapy,the Probiotics can reconstruct the ecological balance of the gut,increase the number of probiotics,foster the growth of normal flora,adjust the intestinal flora,reduce the chance of infection, conducive to the successful completion of chemotherapy,which is worthy of clinical application.
