Allogeneic hematopoietic stem cell transplantation in treatment of acute myeloid leukemia

VernacularTitle:异基因造血干细胞移植治疗急性髓系白血病的现状
Author: Yuewen FU ; Qian WANG ; Yongping SONG
Publication Type:Journal Article
Keywords: Leukemia,myeloid,acute; Allogeneic hematopoietic stem cell transplantation; Genetic characteristics
From: Journal of Leukemia & Lymphoma 2013;22(6):350-353
CountryChina
Language:Chinese
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to acute myeloid leukemia (AML).The therapy effect of allo-HSCT comes from the preconditioning of the radiation and/or chemotherapy,as well as the graft versus leukemia (GVL) effect of the donor' s immune system.In nearly a decade,with the deepening research on biological characteristics of leukemia cells,according to the cytogenetic and molecular markers to dangerous degree classification of AML,which enables us to pick out AML patients can benefit from allo-HSCT.The clinical curative effect of allo-HSCT for AML has obviously improved,and applicable scope has also extended,but there are some differences in the application of AML.The mechanism,opportunity,curative effects,donor selection and preconditioning of allo-HSCT for AML are discussed.