An optimization study of Junkang oral liquid for treatment of patients with acute viral myocarditis
10.3969/j.issn.1008-9691.2015.04.009
- VernacularTitle:君康口服液治疗急性病毒性心肌炎的证治方案研究
- Author:
Yanling WANG
;
Kangkang LI
;
Zengying ZHANG
- Publication Type:Journal Article
- Keywords:
Acute viral myocarditis;
Junkang oral liquid;
Integrated traditional Chinese and western medicine therapy
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2015;(4):370-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore an optimal scheme for diagnosis and treatment of patients with acute viral myocarditis (AVM) with an experience prescription of professor Zhang Zengying, Junkang oral liquid.Methods A prospective study was conducted. Sixty patients with AVM admitted into the Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine (TCM) from March 2012 to January 2014 were randomly divided into two groups: a control group and a treatment group (each, 30 cases). The patients in control group were treated with routine western medicine, including antiviral drugs, polarized solution, adenosine disodiu, and oxygen inhalation; while in treatment group, besides the comprehensive treatment in the control group, the patients were given Junkang oral liquid (main ingredients: Codonopsis pilosula, Salvia miltiorrhiza, Polygonatum odoratum, Notopterygii, Paris polyphylla Smith var. chinensis Hera, Forsythia suspensa, rhizome Ligustici Chunxiong, Hedyotis diffusa, Ophiopogonis tuber), 10 mL each time, three times a day; the treatment was consecutively applied for 3 months in both groups, 15 days constituting one therapeutic course. The changes of cardiac function [heart ejection fraction (EF), stroke volume (SV)] and myocardial enzyme [creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH)], and the TCM syndrome integral score, symptoms and signs such as fever with chills, palpitation or severe palpitation, oppressed feeling in chest, deficiency of qi and disinclination to talk, dizziness, weakness and shortness of breath, spontaneous sweating, night sweating, body limb aches, premature beat shown on electrocardiogram (ECG) and curative effect were observed before and after treatment in the two groups.Results Compared with those before treatment, in the two groups after treatment, the EF and SV were significantly elevated, while the CK, CK-MB, AST, LDH, TCM syndrome integral score were obviously decreased, the degree of improvement in the treatment group being more prominent [EF: 0.601±0.088 vs. 0.538±0.084, SV (mL): 67.02±6.78 vs. 61.03±5.88, CK (U/L): 76.25±28.41 vs. 92.54±31.68, CK-MB (U/L): 18.34±8.94 vs. 22.45±9.70, AST (U/L): 31.29±14.28 vs.33.45±11.21, LDH (μmol·s-1·L-1): 2.28±0.51 vs. 2.34±0.68, TCM syndrome integral score: 12.34±1.24 vs. 18.36±1.98, allP < 0.05]; the degrees of improvement in symptoms and signs such as palpitation or severe palpitation, oppressed feeling in chest, shortness of breath, exhaustion, etc and the total effective rate of premature beat in treatment group were significantly higher than those in the control group [palpitations or severe palpitation: 92.59% (25/27) vs. 75.87% (22/29), oppressed feeling in chest: 92.00% (23/25) vs. 76.92% (20/26), shortness of breath exhaustion: 90.00% (18/20) vs. 76.19% (16/21), premature beat: 88.24% (15/17) vs. 75.00% (12/16), allP < 0.05], and the comparisons of total effective rates between the two groups including fever with chills [100.00% (15/15) vs. 93.75% (15/16)], deficiency of qi and disinclination to talk [88.00% (22/25) vs. 83.33% (15/18)], dizziness [87.50% (7/8) vs. 80.00% (8/10)], spontaneous sweating or night sweating [86.67% (13/15) vs. 80.00% (12/15)] and body limb ache [91.67% (11/12) vs. 84.62% (11/13)] showed no statistical significant differences (allP > 0.05).Conclusion Junkang oral liquid can significantly improve the clinical symptoms in patients with AVM, reverse its acute course and control arrhythmia, showing the advantage in diagnosis and treatment with combination of traditional Chinese and western medicine.
